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Interner Beirat 2019/ 2020 - Beiratsmitglieder

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Institut: Robert Koch-Institut

Expertisen: Parasitologie

Forschungsinteressen: Erreger von Pilz- und Parasiten­infektionen und Myko­bakte­riosen; Verbesserung von Diagnose, Therapie und Prävention dieser Erkrankungen; Epidemiologie; Public Health Aspekte

Wichtige Publikationen (aktuelle Auswahl):

Hellert J, Aebischer A, Wernike K, Haouz A, Brocchi E, Reiche S, Guardado-Calvo P, Beer M, Rey FA. Orthobunyavirus spike architecture and recognition by neutralizing antibodies. Nat Commun. 2019 Feb 20;10(1):879. doi: 10.1038/s41467-019-08832-8.

Geus D, Sifft KC, Habarugira F, Mugisha JC, Mukampunga C, Ndoli J, Bayingana C, Sendegeya A, Martus P, Fraundorfer K, von Samson-Himmelstjerna G, Gahutu JB, Klotz C, Aebischer A, Mockenhaupt FP. Co-infections with Plasmodium, Ascaris and Giardia among Rwandan schoolchildren. Trop Med Int Health. 2019 Apr;24(4):409-420. doi: 10.1111/tmi.13206. Epub 2019 Feb 3

Rehbein S, Klotz C, Ignatius R, Müller E, Aebischer A, Kohn B. Giardia duodenalis in small animals and their owners in Germany: A pilot study. Zoonoses Public Health. 2019 Feb;66(1):117-124. doi: 10.1111/zph.12541. Epub 2018 Nov 20.

Wernike K, Mundt A, Link EK, Aebischer A, Schlotthauer F, Sutter G, Fux R, Beer M. N-terminal domain of Schmallenberg virus envelope protein Gc delivered by recombinant equine herpesvirus type 1 and modified vaccinia virus Ankara: Immunogenicity and protective efficacy in cattle. Vaccine. 2018 Aug 16;36(34):5116-5123. doi: 10.1016/j.vaccine.2018.07.047. Epub 2018 Jul 23

Wernike K, Michelitsch A, Aebischer A, Schaarschmidt U, Konrath A, Nieper H, Sehl J, Teifke JP, Beer M.The Occurrence of a Commercial Npro and Erns Double Mutant BVDV-1 Live-Vaccine Strain in Newborn Calves. Viruses. 2018 May 19;10(5). pii: E274. doi: 10.3390/v10050274.

Bild Sascha Al-Dahouk

Institut: Bundesinstitut für Risikobewertung, Abteilung Biologische Sicherheit

Expertisen: Klinische Infektiologie, Mikrobiologie und Infektionsepidemiologie, Public Health

Forschungsinteressen: Hochpathogene mikrobielle Erreger; Identifizierung und Charakterisierung neuartiger bakterieller Bedrohungen entlang der Lebensmittelkette; Diagnostik und Feintypisierung von Bakterien; Erreger-Wirt-Interaktion

Wichtige Publikationen (aktuelle Auswahl):

Hackert VH, J P A Hoebe C, Dukers-Muijrers N, Krafft T, Kauhl B, Henning K,Karges W, Sprague L, Neubauer H, Al Dahouk S. Q Fever: Evidence of a Massive Yet
Undetected Cross-Border Outbreak, With Ongoing Risk of Extra Mortality, in a Dutch-German Border Region. Transbound Emerg Dis. 2020 Feb 6. doi:10.1111/tbed.13505. [Epub ahead of print] PubMed PMID: 32027783.

Ouahrani-Bettache S, Jiménez De Bagüés MP, De La Garza J, Freddi L, Bueso JP, Lyonnais S, Al Dahouk S, De Biase D, Köhler S, Occhialini A. Lethality of Brucella microti in a murine model of infection depends on the wbkE gene involved in O-polysaccharide synthesis. Virulence. 2019 Dec;10(1):868-878. doi: 10.1080/21505594.2019.1682762. PubMed PMID: 31635539; PubMed Central PMCID:PMC6844557.

Freddi L, Damiano MA, Chaloin L, Pennacchietti E, Al Dahouk S, Köhler S, De Biase D, Occhialini A. The Glutaminase-Dependent System Confers Extreme Acid
Resistance to New Species and Atypical Strains of Brucella. Front Microbiol. 2017 Nov 15;8:2236. doi: 10.3389/fmicb.2017.02236. eCollection 2017. PubMed PMID: 29187839; PubMed Central PMCID: PMC5695133.

Kleta S, Hammerl JA, Dieckmann R, Malorny B, Borowiak M, Halbedel S, Prager R,Trost E, Flieger A, Wilking H, Vygen-Bonnet S, Busch U, Messelhäußer U, Horlacher
S, Schönberger K, Lohr D, Aichinger E, Luber P, Hensel A, Al Dahouk S. Molecular Tracing to Find Source of Protracted Invasive Listeriosis Outbreak, Southern Germany, 2012-2016. Emerg Infect Dis. 2017 Oct;23(10):1680-1683. doi: 10.3201/eid2310.161623. PubMed PMID: 28930013; PubMed Central PMCID: PMC5621528.

Rohde A, Hammerl JA, Appel B, Dieckmann R, Al Dahouk S. Differential detection of pathogenic Yersinia spp. by fluorescence in situ hybridization. Food Microbiol. 2017 Apr;62:39-45. doi: 10.1016/j.fm.2016.09.013. Epub 2016 Sep 21. PubMed PMID: 27889163.

Al Dahouk S, Köhler S, Occhialini A, Jiménez de Bagüés MP, Hammerl JA, Eisenberg T, Vergnaud G, Cloeckaert A, Zygmunt MS, Whatmore AM, Melzer F, Drees KP, Foster JT, Wattam AR, Scholz HC. Brucella spp. of amphibians comprise genomically diverse motile strains competent for replication in macrophages and survival in mammalian hosts. Sci Rep. 2017 Mar 16;7:44420. doi: 10.1038/srep44420. PubMed PMID: 28300153; PubMed Central PMCID: PMC5353553.

Julia Assmann

Institut: Robert Koch-Institut

Expertisen: Mikrobiologie, Bakteriologie, Molekularbiologie

Forschungsinteressen: Biofilme, bakterielle Kommunikation, One Health

Stefanie Becker

Institut: Institut für Parasitologie, Stiftung Tierärztliche Hochschule Hannover

Expertisen: Vektorökologie, Taxonomie und Populationsgenetik, Vektor-/Insektenimmunität, Virusgenetik, Evolution und Ökologie, Co-Infektionen und Mikrobiome

Forschungsinteressen: Arthropoden-übertragene Viren (Arboviren) wie Flaviviridae (West-Nil-Virus (WNV)), Tick-borne Enzephalitis-Virus (TBEV)), Bunyaviriales (Rift Valley Fiebervirus (RVFV)) und Bunyamwera orthobunyavirus (BUNV)); arbovirale Übertragung auf Mensch und Tier; Verteilung von Mücken, Zecken und Arboviren, Populationsgenetik und Ökologie; Vektor-Kompetenzstudien; Vektorimmunität; Vektorphysiologie; Vektor- und Virusgenetik, Vektor-Mikrobiom-Interaktionen.

Wichtige Publikationen (Auswahl):       

Mathias Boelke, Malena Bestehorn , Birgit Marchwald , Mareike Kubinski , Katrin Liebig , Julien Glanz Claudia Schulz , Gerhard Dobler , Masyar Monazahian , Stefanie C. Becker. First isolation and phylogenetic analyses of tick-borne encephalitis virus in Lower Saxony, Germany. Viruses (2019) DOI 10.3390/v11050462

Kati Franzke, Mayke Leggewie, Vattipally B. Sreenu,  Stephanie Jansen , Anna Heitmann , Stephen R. Welch,  Benjamin Brennan,  Richard M. Elliott,  Egbert Tannich, Stefanie C. Becker, Esther Schnettler. Detection, infection dynamics and small RNA response against Culex Y virus in mosquito-derived cells. Journal of general Virology (2018) DOI 10.1099/jgv.0.001173.

Isabelle Dietrich , Stephanie Jansen ,  Gamou Fall , Stephan Lorenzen , Martin Rudolf , Katrin  Huber , Anna Heitmann ,Sabine Schicht , El Hadji Ndiaye, Mick   Watson, Ilaria Castelli , Benjamin Brennan, Richard M. Elliott, Mawlouth Diallo,  Amadou A. Sall, Anna-Bella Failloux, Esther Schnettler, Alain Kohl, Stefanie C. Becker. RNA interference restricts Rift Valley fever virus in multiple insect systems.  mSphere (2017) DOI 2:e00090-17

Mayke Leggewie, Marlis Badusche, Martin Rudolf, Stephanie Jansen, Jessica Börstler, Ralf Krumkamp, Katrin Huber, Andreas Krüger, Jonas Schmidt-Chanasit, Egbert Tannich, Stefanie C. Becker. Culex pipiens and Culex torrentium populations from Central Europe are susceptible to West Nile virus infection. One Health 2 (2016), DOI 0.1016/j.onehlt.2016.04.001. Journal of Medical Entomology (2015) 1-5, DOI: 10.1093/jme/tjv070

Katrin Huber, Kathrin Schuldt, Martin Rudolf, Marco Marklewitz, Dina M Fonseca, Christian Kaufmann, Yoshio Tsuda, Sandra Junglen, Andreas Krüger, Norbert Becker, Egbert Tannich, Stefanie C Becker. Distribution and genetic structure of Aedes japonicus japonicus populations (Diptera: Culicidae) in Germany. Parasitology research (2014) DOI: 10.1007/s00436-014-4000-z

Katrin Huber, Stephanie Jansen, Mayke Leggewie, Marlis Badusche, Jonas Schmidt-Chanasit, Norbert Becker, Egbert Tannich, Stefanie C Becker. Aedes japonicus japonicus (Diptera: Culicidae) from Germany have vector competence for Japan encephalitis virus but are refractory to infection with West Nile virus. Parasitology research 2014; DOI: 10.1007/s00436-014-3983-9

Nadine Reiter, Marielies Reiter, Sabine Altrichter, Stefanie Becker, Thomas Kristensen, Sigrund Broesby-Olsen, Martin K. Church, Martin Metz, Marcus Maurer, and Frank Siebenhaar. Anaphylaxis caused by mosquito allergy in systemic mastocytosis Lancet, (2013) DOI: 10.1016/S0140-6736(13)61605-0

Cordula Kemp*, Stefanie Müller*, Akira Goto, Vincent Barbier, Simona Paro, François Bonnay, Catherine Dostert, Laurent Troxler, Charles Hetru, Carine Meignin, Sébastien Pfeffer, Jules A Hoffmann and Jean-Luc Imler. Broad RNA Interference-Mediated Antiviral Immunity and Virus-Specific Inducible Responses in Drosophila. The Journal of Immunology (2012) DOI: 10.4049/jimmunol.1102486;* equal contribution

Stefanie Müller, Valérie Gausson, Nicolas Vodovar, Safia Deddouche, Laurent Troxler, Jonathan Perot, Sébastien Pfeffer, Jules A Hoffmann, Maria-Carla Saleh and Jean-Luc Imler. RNAi-mediated immunity provides strong protection against the negative-strand RNA vesicular stomatitis virus in Drosophila. Proceedings of the National Academy of Sciences (2010) DOI:10.1073/pnas.1014378107 10

Safia Deddouche, Nicolas Matt, Aidan Budd, Stefanie Müller, Cordula Kemp, Delphine Galiana-Arnoux, Catherine Dostert, Christophe Antoniewski, Jules A Hoffmann and Jean-Luc Imler. The DExD/H-box helicase Dicer-2 mediates the induction of antiviral activity in drosophila. Nature Immunology (2008) DOI: 10.1038/ni.1664

Bild Martin Beer

Institut: Institut für Virusdiagnostik, Friedrich-Loeffler-Institut

Expertisen: Fachtierarzt für Virologie, Fachtierarzt für Mikrobiologie

Forschungsinteressen:  veterinärmedizinisch bedeutsame Viruserkrankungen; Diagnostik und Differentialdiagnostik

Wichtige Publikationen (aktuelle Auswahl):

Niller HH, Angstwurm K, Rubbenstroth D, Schlottau K, Ebinger A, Giese S, Wunderlich S, Banas B, Forth LF, Hoffmann D, Höper D, Schwemmle M, Tappe D, Schmidt-Chanasit J, Nobach D, Herden C, Brochhausen C, Velez-Char N, Mamilos A, Utpatel K, Evert M, Zoubaa S, Riemenschneider MJ, Ruf V, Herms J, Rieder G, Errath M, Matiasek K, Schlegel J, Liesche-Starnecker F, Neumann B, Fuchs K, Linker RA, Salzberger B, Freilinger T, Gartner L, Wenzel JJ, Reischl U, Jilg W, Gessner A, Jantsch J, Beer M, Schmidt B. Zoonotic spillover infections with Borna disease virus 1 leading to fatal human encephalitis, 1999-2019: an epidemiological investigation. Lancet Infect Dis. 2020 Jan 7. pii: S1473-3099(19)30546-8. doi: 10.1016/S1473-3099(19)30546-8.

Tappe D, Frank C, Offergeld R, Wagner-Wiening C, Stark K, Rubbenstroth D, Giese S, Lattwein E, Schwemmle M, Beer M, Schmidt-Chanasit J, Wilking H. Low prevalence of Borna disease virus 1 (BoDV-1) IgG antibodies in humans from areas endemic for animal Borna disease of Southern Germany. Sci Rep. 2019 Dec 27;9(1):20154. doi: 10.1038/s41598-019-56839-4.

Hassan KE, King J, El-Kady M, Afifi M, Abozeid HH, Pohlmann A, Beer M, Harder T. Novel Reassortant Highly Pathogenic Avian Influenza A(H5N2) Virus in Broiler Chickens, Egypt. Emerg Infect Dis. 2020 Jan;26(1):129-133. doi: 10.3201/eid2601.190570.

Schlottau K, Eggerbauer E, Freuling CM, Beer M, Müller T, Hoffmann B. Rapid molecular species identification of indigenous bats from Germany for surveillance purposes. Infect Genet Evol. 2019 Dec 13;78:104140. doi: 10.1016/j.meegid.2019.104140.

Schulz C, Fast C, Wernery U, Kinne J, Joseph S, Schlottau K, Jenckel M, Höper D, Patteril NAG, Syriac G, Hoffmann B, Beer M. Camelids and Cattle Are Dead-End Hosts for Peste-des-Petits-Ruminants Virus. Viruses. 2019 Dec 8;11(12). pii: E1133. doi: 10.3390/v11121133

Bild Stefan_ Bereswill

Institut: Institut für Mikrobiologie, AG Gastrointestinale Mikrobiologie, Charité Universitätsmedizin Berlin

Expertisen: Gastrointestinale Mikrobiologie

Forschungsinteressen: Prävention und Therapie der Campylobacter-Infektion in präklinischen Modellsystemen; Grundlagen der Etablierung und Persistenz Multiresistenter Gram-negativer Bakterien (MRGN) im Gastrointestinaltrakt

Publikationen (aktuelle):

Stephany-Brassesco I, Bereswill S, Heimesaat MM, Melzig MF. Synergistic Antimicrobial Effects of Cefabronchin®. Eur J Microbiol Immunol (Bp). 2019 Jun 27;9(3):100-104. doi: 10.1556/1886.2019.00009. eCollection 2019 Oct 3.

Golpour A, Bereswill S, Heimesaat MM.Antimicrobial and Immune-Modulatory Effects of Vitamin D Provide Promising Antibiotics-Independent Approaches to Tackle Bacterial Infections - Lessons Learnt from a Literature Survey. Eur J Microbiol Immunol (Bp). 2019 Aug 13;9(3):80-87. doi: 10.1556/1886.2019.00014. eCollection 2019 Oct 3. Review.

Mousavi S, Bereswill S, Heimesaat MM. Immunomodulatory and Antimicrobial Effects of Vitamin C. Eur J Microbiol Immunol (Bp). 2019 Aug 16;9(3):73-79. doi: 10.1556/1886.2019.00016. eCollection 2019 Oct 3. Review.

Heimesaat MM, Mrazek K, Bereswill S. Murine Fecal Microbiota Transplantation Alleviates Intestinal and Systemic Immune Responses in Campylobacter jejuni Infected Mice Harboring a Human Gut Microbiota. Front Immunol. 2019 Sep 24;10:2272. doi: 10.3389/fimmu.2019.02272. eCollection 2019.

Lobo de Sá FD, Butkevych E, Nattramilarasu PK, Fromm A, Mousavi S, Moos V, Golz JC, Stingl K, Kittler S, Seinige D, Kehrenberg C, Heimesaat MM, Bereswill S, Schulzke JD, Bücker R. Curcumin Mitigates Immune-Induced Epithelial Barrier Dysfunction by Campylobacter jejuni. Int J Mol Sci. 2019 Sep 28;20(19). pii: E4830. doi: 10.3390/ijms20194830.

Mousavi S, Lobo de Sá FD, Schulzke JD, Bücker R, Bereswill S, Heimesaat MM. Vitamin D in Acute Campylobacteriosis-Results From an Intervention Study Applying a Clinical Campylobacter jejuni Induced Enterocolitis Model. Front Immunol. 2019 Sep 3;10:2094. doi: 10.3389/fimmu.2019.02094. eCollection 2019.

Schmidt AM, Escher U, Mousavi S, Tegtmeyer N, Boehm M, Backert S, Bereswill S, Heimesaat MM.Immunopathological properties of the Campylobacter jejuni flagellins and the adhesin CadF as assessed in a clinical murine infection model. Gut Pathog. 2019 May 17;11:24. doi: 10.1186/s13099-019-0306-9. eCollection 2019.

Heimesaat MM, Dunay IR, Bereswill S. Comprehensive Kinetic Survey of Intestinal, Extra-Intestinal and Systemic Sequelae of Murine Ileitis Following Peroral Low-Dose Toxoplasma gondii Infection. Front Cell Infect Microbiol. 2019 Apr 12;9:98. doi: 10.3389/fcimb.2019.00098. eCollection 2019.

Schmidt AM, Escher U, Mousavi S, Boehm M, Backert S, Bereswill S, Heimesaat MM. Protease Activity of Campylobacter jejuni HtrA Modulates Distinct Intestinal and Systemic Immune Responses in Infected Secondary Abiotic IL-10 Deficient Mice. Front Cell Infect Microbiol. 2019 Mar 29;9:79. doi: 10.3389/fcimb.2019.00079. eCollection 2019.

Mrazek K, Bereswill S, Heimesaat MM. Fecal Microbiota Transplantation Decreases Intestinal Loads of Multi-Drug Resistant Pseudomonas aeruginosa in Murine Carriers. Eur J Microbiol Immunol (Bp). 2019 Mar 4;9(1):14-22. doi: 10.1556/1886.2019.00002. eCollection 2019 Mar 18.

weitere Publikationen: https://www.ncbi.nlm.nih.gov/pubmed?term=Bereswill+S&cmd=DetailsSearch

Bild Martin Blume

Institut: Robert Koch-Institut

Expertisen: Stoffwechsel mikrobieller Pathogene

Forschungsinteressen: zoonotische Infektionen durch Bakterien, Pilze und Parasiten; Zellstoffwechsel - und Physiologie; neue Chemotherapien gegen persistierende zoonotische Infektionen

Wichtige Publikationen (aktuelle Auswahl):

Parker KER, Fairweather SJ, Rajendran E, Blume M, McConville MJ, Bröer S, Kirk K, van Dooren GG. The tyrosine transporter of Toxoplasma gondii is a member of the newly defined apicomplexan amino acid transporter (ApiAT) family. PLoS Pathog. 2019 Feb 11;15(2):e1007577. doi: 10.1371/journal.ppat.1007577. eCollection 2019 Feb.

Blume M, Seeber F.Metabolic interactions between Toxoplasma gondii and its host. F1000Res. 2018 Oct 30;7. pii: F1000 Faculty Rev-1719. doi: 10.12688/f1000research.16021.1. eCollection 2018. Review

Kloehn J, Blume M, Cobbold SA, Saunders EC, Dagley MJ, McConville MJ. Using metabolomics to dissect host-parasite interactions. Curr Opin Microbiol. 2016 Aug;32:59-65. doi: 10.1016/j.mib.2016.04.019. Epub 2016 May 17. Review.

Uboldi AD, McCoy JM, Blume M, Gerlic M, Ferguson DJ, Dagley LF, Beahan CT, Stapleton DI, Gooley PR, Bacic A, Masters SL, Webb AI, McConville MJ, Tonkin CJ. Regulation of Starch Stores by a Ca(2+)-Dependent Protein Kinase Is Essential for Viable Cyst Development in Toxoplasma gondii. Cell Host Microbe. 2015 Dec 9;18(6):670-81. doi: 10.1016/j.chom.2015.11.004.

Blume M, Nitzsche R, Sternberg U, Gerlic M, Masters SL, Gupta N, McConville MJ. A Toxoplasma gondii Gluconeogenic Enzyme Contributes to Robust Central Carbon Metabolism and Is Essential for Replication and Virulence. Cell Host Microbe. 2015 Aug 12;18(2):210-20. doi: 10.1016/j.chom.2015.07.008

Bild Victor Corman

Institut: Institut für Virologie , Charite - Universitätsmedizin Berlin

Expertisen: klinische Virologie, Diagnostika und die Charakterisierung neu auftretender Viren im Menschen

Forschungsinteressen: Diversität und Evolution von RNA-Viren, insbesondere von zoonotischen Viren, die ihr Reservoir in anderen Säugetieren haben und teils pathogen für den Menschen sind; Hepatitis E-Virus; MERS-Coronavirus

Wichtige Publikationen (Auswahl):

Corman VM, Eckerle I, Memish ZA, Liljander AM, Dijkman R, Jonsdottir H, Juma Ngeiywa KJ, Kamau E, Younan M, Al Masri M, Assiri A, Gluecks I, Musa BE, Meyer B, Müller MA, Hilali M, Bornstein S, Wernery U, Thiel V, Jores J, Drexler JF, Drosten C. Link of a ubiquitous human coronavirus to dromedary camels. Proc Natl Acad Sci U S A. 2016 Aug 30;113(35):9864-9. doi: 10.1073/pnas.1604472113.

Rasche A, Saqib M, Liljander AM, Bornstein S, Zohaib A, Renneker S, Steinhagen K, Wernery R, Younan M, Gluecks I, Hilali M, Musa BE, Jores J, Wernery U, Drexler JF, Drosten C, Corman VM. Hepatitis E Virus Infection in Dromedaries, North and East Africa, United Arab Emirates, and Pakistan, 1983-2015. Emerg Infect Dis. 2016 Jul;22(7):1249-52. doi: 10.3201/eid2207.160168. Erratum in: Emerg Infect Dis. 2017 Mar;23(3):560.

Corman VM, Albarrak AM, Omrani AS, Albarrak MM, Farah ME, Almasri M, Muth D, Sieberg A, Meyer B, Assiri AM, Binger T, Steinhagen K, Lattwein E, Al-Tawfiq J, Müller MA, Drosten C, Memish ZA. Viral Shedding and Antibody Response in 37 Patients With Middle East Respiratory Syndrome Coronavirus Infection. Clin Infect Dis. 2016 Feb 15;62(4):477-83. doi: 10.1093/cid/civ951.

Corman VM, Eckerle I, Bleicker T, Zaki A, Landt O, Eschbach-Bludau M, van Boheemen S, Gopal R, Ballhause M, Bestebroer TM, Muth D, Müller MA, Drexler JF, Zambon M, Osterhaus AD, Fouchier RM, Drosten C. Detection of a novel human coronavirus by real-time reverse-transcription polymerase chain reaction. Euro Surveill. 2012 Sep 27;17(39). pii: 20285. Erratum in: Euro Surveill. 2012;17(40): pii/20288.

Bild Stefan Brockmann

Institut: Regierungspräsidium Stuttgart - Referat 92 - Gesundheitsschutz und Epidemiologie

Expertisen: Epidemiologie, Mikrobiologie, Hygiene

Forschungsinteressen: Infektionsschutz, Surveillance, umweltbezogener Gesundheitsschutz

Wichtige Publikationen (aktuelle Auswahl):

Binder F, Drewes S, Imholt C, Saathoff M, Below DA, Bendl E, Conraths FJ, Tenhaken P, Mylius M, Brockmann S, Oehme R, Freise J, Jacob J, Ulrich RG. Heterogeneous Puumala orthohantavirus situation in endemic regions in Germany in summer 2019. Transbound Emerg Dis. 2019 Nov 1. doi: 10.1111/tbed.13408.

Brockmann SO, Eichner L, Eichner M. Constantly high incidence of scarlet fever in Germany. Lancet Infect Dis. 2018 May;18(5):499-500. doi: 10.1016/S1473-3099(18)30210-X.

Brockmann SO, Oehme R, Buckenmaier T, Beer M, Jeffery-Smith A, Spannenkrebs M, Haag-Milz S, Wagner-Wiening C, Schlegel C, Fritz J, Zange S, Bestehorn M, Lindau A, Hoffmann D, Tiberi S, Mackenstedt U, Dobler G. A cluster of two human cases of tick-borne encephalitis (TBE) transmitted by unpasteurised goat milk and cheese in Germany, May 2016. Euro Surveill. 2018 Apr;23(15). doi: 10.2807/1560-7917.ES.2018.23.15.17-00336.

Miller T, Brockmann S, Spackova M, Wetzig J, Frank C, Pfeifer Y, Braun PG, Prager R, Rabsch W. Recurrent outbreaks caused by the same Salmonella enterica serovar Infantis clone in a German rehabilitation oncology clinic from 2002 to 2009. J Hosp Infect. 2018 Dec;100(4):e233-e238. doi: 10.1016/j.jhin.2018.03.035. Epub 2018 Mar 31.

Eichner L, Wjst S, Brockmann SO, Wolfers K, Eichner M. Local measles vaccination gaps in Germany and the role of vaccination providers. BMC Public Health. 2017 Aug 14;17(1):656. doi: 10.1186/s12889-017-4663-3.

Brockmann SO, Ulrich L, Piechotowski I, Wagner-Wiening C, Nöckler K, Mayer-Scholl A, Eichner M. Risk factors for human Leptospira seropositivity in South Germany. Springerplus. 2016 Oct 18;5(1):1796. eCollection 2016.

Bild Gerhard Dobler

Institut: Institut für Mikrobiologie der Bundeswehr

Expertisen: Epidemiologie, Diagnostik und Prophylaxe von Flaviviren und Alphaviren; Nationales Konsiliarlabor für FSME

Forschungsinteressen: Öko-Epidemiologie, Öko-Pathologie von Vektor-übertragenen Zoonosen

wichtige Publikationen (Auswahl):

Borde JP, Kaier K, Hehn P, Böhmer MM, Kreusch TM, Dobler G (2019). Tick-borne encephalitis virus infections in Germany. Seasonality and in-year pattern. A retrospective analysis from 2001-2018. PLoS One 14(10):e0224044.

Chitimia-Dobler L, Issa MH, Ezalden ME, Yagoub IA, Abdalla MA, Bakhiet AO, Schaper S, Rieß R, Vollmar P, Grumbach A, Bestehorn M, Antwerpen M, Dobler G, Shuaib YA (2019). Crimean-Congo haemorrhagic fever virus in Hyalomma impeltatum ticks from North Kordofan, the Sudan. Int J Inf Dis. S1201-9712(19)30374-1.

Chitimia-Dobler L, Schaper S, Ries R, Bitterwol K, Frangoulidis D, Bestehorn M, Springer A, Drehmann M, Lindau A, Mackenstedt U, Strube C, Dobler G (2019). Imported Hyalomma ticks in Germany in 2018. 2019. Parasites Vectors (2019) 12:134.
Chitimia-Dobler L, Lemhöfer G, Krol N, Bestehorn M, Dobler G, Pfeffer M (2019). Repeated isolation of tick-borne encephalitis virus from adult Dermacentor reticulatus ticks in an endemic area in Germany. 2019. Parasites Vectors (2019)12:90.

Dobler G, Kaier K, Hen P, Böhmer MM, Kreusch TM, Borde JP (2019). Tick-borne encephalitis virus vacicnation breakthrough infections in Germany – a retrospective analysis from 2001 – 2018. Clin Microbiol Infect (accepted).

Hellenbrand W, Kreusch T, Böhmer MM, Wagner-Wiening C, Dobler G, Wichmann O, Altmann D (2019). Epidemiology of tick-borne encephalitis (TBE) in Germany 2001-2018. Pathogens 2019, 8, 42.
 

Bestehorn M, Weigold S, Kern WV, Chitimia-Dobler L, Mackenstedt U, Dobler G, Borde J (2018). Phylogenetics of tick-borne encephalitis virus in endemic foci in the upper Rhine region in France and Germany. PLOS One. 13(10):e0204790.

Brockmann SO, Oehme R, Buckenmaier T, Beer M, Jeffery-Smith A, Spannenkrebs M, Haag-Milz S, Wagner-Wiening C, Schlegel C, Fritz J, Zange S, Bestehorn M, Lindau A, Hoffmann D, Tiberi S, Mackenstedt U, Dobler G (2018). A cluster of two human cases of tick-borne encephalitis (TBE) transmitted by unpasteurised goat milk and cheese in Germany, May 2016. Euro Surveill. Apr;23(15).

Bild Christian_Drosten (Foto: Wibke Peitz)

Institut: Institut für Virologie, Charité - Universitätsmedizin Berlin

Expertisen: klinische Virologie, Molekulardiagnostik, Mikrobiologie und Infektionsepidemiologie

Forschungsinteressen: Virusökologie und Artenbarrieren bei neu auftretenden Viruserkrankungen; Coronavirus; SARS; Arboviren; Molekulardiagnostik; Vorhersage, Überwachung und Diagnose von Virusinfektionen

Wichtige Publikationen (aktuelle Auswahl):

Gassen NC, Niemeyer D, Muth D, Corman VM, Martinelli S, Gassen A, Hafner K, Papies J, Mösbauer K, Zellner A, Zannas AS, Herrmann A, Holsboer F, Brack-Werner R, Boshart M, Müller-Myhsok B, Drosten C, Müller MA, Rein T. SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection. Nat Commun. 2019 Dec 18;10(1):5770. doi: 10.1038/s41467-019-13659-4.

El-Kafrawy SA, Corman VM, Tolah AM, Al Masaudi SB, Hassan AM, Müller MA, Bleicker T, Harakeh SM, Alzahrani AA, Alsaaidi GA, Alagili AN, Hashem AM, Zumla A, Drosten C, Azhar EI. Enzootic patterns of Middle East respiratory syndrome coronavirus in imported African and local Arabian dromedary camels: a prospective genomic study. Lancet Planet Health. 2019 Dec;3(12):e521-e528. doi: 10.1016/S2542-5196(19)30243-8. Epub 2019 Dec 16.

Käfer S, Paraskevopoulou S, Zirkel F, Wieseke N, Donath A, Petersen M, Jones TC, Liu S, Zhou X, Middendorf M, Junglen S, Misof B, Drosten C. Re-assessing the diversity of negative strand RNA viruses in insects. PLoS Pathog. 2019 Dec 12;15(12):e1008224. doi: 10.1371/journal.ppat.1008224. eCollection 2019 Dec.

Hermanns K, Marklewitz M, Zirkel F, Overheul GJ, Page RA, Loaiza JR, Drosten C, van Rij RP, Junglen S. Agua Salud alphavirus defines a novel lineage of insect-specific alphaviruses discovered in the New World. J Gen Virol. 2019 Nov 1. doi: 10.1099/jgv.0.001344.

Azhar EI, Hui DSC, Memish ZA, Drosten C, Zumla A. The Middle East Respiratory Syndrome (MERS). Infect Dis Clin North Am. 2019 Dec;33(4):891-905. doi: 10.1016/j.idc.2019.08.001. Review.

Wasimuddin, Corman VM, Ganzhorn JU, Rakotondranary J, Ratovonamana YR, Drosten C, Sommer S. Adenovirus infection is associated with altered gut microbial communities in a non-human primate. Sci Rep. 2019 Sep 16;9(1):13410. doi: 10.1038/s41598-019-49829-z.

Voigt K, Hoffmann M, Drexler JF, Müller MA, Drosten C, Herrler G, Krüger N. Fusogenicity of the Ghana Virus (Henipavirus: Ghanaian bat henipavirus) Fusion Protein is Controlled by the Cytoplasmic Domain of the Attachment Glycoprotein. Viruses. 2019 Aug 29;11(9). pii: E800. doi: 10.3390/v11090800.

Hölzer M, Schoen A, Wulle J, Müller MA, Drosten C, Marz M, Weber F. Virus- and Interferon Alpha-Induced Transcriptomes of Cells from the Microbat Myotis daubentonii. iScience. 2019 Sep 27;19:647-661. doi: 10.1016/j.isci.2019.08.016.

Harvey R, Mattiuzzo G, Hassall M, Sieberg A, Müller MA, Drosten C, Rigsby P, Oxenford CJ; study participants. Comparison of Serologic Assays for Middle East Respiratory Syndrome Coronavirus. Emerg Infect Dis. 2019 Oct;25(10):1878-1883. doi: 10.3201/eid2510.190497.

Mühlemann B, Jones TC, Damgaard PB, Allentoft ME, Shevnina I, Logvin A, Usmanova E, Panyushkina IP, Boldgiv B, Bazartseren T, Tashbaeva K, Merz V, Lau N, Smrčka V, Voyakin D, Kitov E, Epimakhov A, Pokutta D, Vicze M, Price TD, Moiseyev V, Hansen AJ, Orlando L, Rasmussen S, Sikora M, Vinner L, Osterhaus ADME, Smith DJ, Glebe D, Fouchier RAM, Drosten C, Sjögren KG, Kristiansen K, Willerslev E. Ancient hepatitis B viruses from the Bronze Age to the Medieval period. Nature. 2018 May;557(7705):418-423. doi: 10.1038/s41586-018-0097-z. Erratum in: Nature. 2018 Oct;562(7726):E4.

Bild Sandra Eßbauer

Institut: Institut für Mikrobiologie der Bundeswehr

Expertise: Virologie, Epidemiologie

Forschungsinteressen: Hämorrhagische Fieber, Rickettsien, FSMEV, Naturherde

Wichtige Publikationen (Auswahl):

Turebekov N, Abdiyeva K, Yegemberdiyeva R, Dmitrovsky A, Yeraliyeva L, Shapiyeva Z, Amirbekov A, Oradova A, Kachiyeva Z, Ziyadina L, Hoelscher M, Froeschl G, Dobler G, Zinner J, Frey S, Essbauer S. Prevalence of Rickettsia species in ticks including identification of unknown species in two regions in Kazakhstan. Parasit Vectors. 2019 May 3;12(1):197. doi: 10.1186/s13071-019-3440-9. PubMed PMID: 31053085; PubMed Central PMCID: PMC6500025.

Abdiyeva K, Turebekov N, Dmitrovsky A, Tukhanova N, Shin A, Yeraliyeva L, Heinrich N, Hoelscher M, Yegemberdiyeva R, Shapiyeva Z, Kachiyeva Z, Zhalmagambetova A, Montag J, Dobler G, Zinner J, Wagner E, Frey S, Essbauer S. Seroepidemiological and molecular investigations of infections with Crimean-Congo haemorrhagic fever virus in Kazakhstan. Int J Infect Dis. 2019 Jan;78:121-127. doi: 10.1016/j.ijid.2018.10.015. Epub 2018 Oct 25. PubMed PMID: 30522982.

Speck S, Kern T, Aistleitner K, Dilcher M, Dobler G, Essbauer S. In vitro studies of Rickettsia-host cell interactions: Confocal laser scanning microscopy  of Rickettsia helvetica-infected eukaryotic cell lines. PLoS Negl Trop Dis. 2018 Feb 12;12(2):e0006151. doi: 10.1371/journal.pntd.0006151. eCollection 2018 Feb. PubMed PMID: 29432420; PubMed Central PMCID: PMC5825168.

Essbauer S, Hofmann M, Kleinemeier C, Wölfel S, Matthee S. Rickettsia diversity in southern Africa: A small mammal perspective. Ticks Tick Borne Dis. 2018 Feb;9(2):288-301. doi: 10.1016/j.ttbdis.2017.11.002. Epub 2017 Nov 14. PubMed PMID: 29174365.

Vollmar P, Lubnow M, Simon M, Müller T, Bergler T, Alois P, Thoma BR, Essbauer S. Hantavirus cardiopulmonary syndrome due to Puumala virus in Germany. J Clin Virol. 2016 Nov;84:42-47. doi: 10.1016/j.jcv.2016.10.004. Epub 2016 Oct 4. PubMed PMID: 27721108

Bild Stefan Brockmann

Institut: Leiter des Veterinärdienstes bei Landkreis Osnabrück

Expertisen: 

Forschungsinteressen: 

Wichtige Publikationen:

 

Bild Martin Groschup

Institut: Institut für neue und neuartige Tierseuchenerreger (INNT), Friedrich-Loeffler-Institut

Expertisen: Fachtierarzt für Mikrobiologie, Fachtierarzt für Virologie, Diagnostik, Surveillance

Forschungsinteressen: neuartige Tierseuchenerreger, virale Zoonosen

Wichtige Publikationen (aktuelle): 

Claudia Filippone, Guillaume Castel, Séverine Murri, Myriam Ermonval, Misa Korva, Tatjana Avšič-Županc, Tarja Sironen, Olli Vapalahati, Lorraine M. McElhinney, Rainer G. Ulrich, Martin H. Groschup, Valérie Caro, Frank Sauvage, Sylvie van der Werf, Jean-Claude Manuguerra, Antoine Gessain, Philippe Marianneau, Noël Tordo. Revisiting the genetic diversity of emerging hantaviruses circulating in Europe using a pan-viral resequencing microarray. Sci Rep. 2019; 9: 12404. Published online 2019 Aug 27. doi: 10.1038/s41598-019-47508-7

Friederike Michel, Michael Sieg, Dominik Fischer, Markus Keller, Martin Eiden, Maximilian Reuschel, Volker Schmidt, Rebekka Schwehn, Monika Rinder, Sylvia Urbaniak, Kerstin Müller, Martina Schmoock, Renke Lühken, Patrick Wysocki, Christine Fast, Michael Lierz, Rüdiger Korbel, Thomas W. Vahlenkamp, Martin H. Groschup, Ute Ziegler. Evidence for West Nile Virus and Usutu Virus Infections in Wild and Resident Birds in Germany, 2017 and 2018. Viruses. 2019 Jul; 11(7): 674. Published online 2019 Jul 23. doi: 10.3390/v11070674

Christine Fast, Markus Keller, Martin Kaatz, Ute Ziegler, Martin H. Groschup. Low levels of classical BSE infectivity in rendered fat tissue. Vet Res. 2018; 49: 122. Published online 2018 Dec 20. doi: 10.1186/s13567-018-0618-7

Josephine Schlosser, Lisa Dähnert, Paul Dremsek, Kerstin Tauscher, Christine Fast, Ute Ziegler, Albrecht Gröner, Rainer G Ulrich, Martin H Groschup, Martin Eiden. Different Outcomes of Experimental Hepatitis E Virus Infection in Diverse Mouse Strains, Wistar Rats, and Rabbits. Viruses. 2019 Jan; 11(1): 1. Published online 2018 Dec 20. doi: 10.3390/v11010001

Nicholas Johnson, Mar Fernández de Marco, Armando Giovannini, Carla Ippoliti, Maria Luisa Danzetta, Gili Svartz, Oran Erster, Martin H. Groschup, Ute Ziegler, Ali Mirazimi, Vanessa Monteil, Cecile Beck, Gaelle Gonzalez, Sylvie Lecollinet, Houssam Attoui, Sara Moutailler. Emerging Mosquito-Borne Threats and the Response from European and Eastern Mediterranean Countries. Int J Environ Res Public Health. 2018 Dec; 15(12): 2775. Published online 2018 Dec 7. doi: 10.3390/ijerph15122775

Lisa Dähnert, Martin Eiden, Josephine Schlosser, Christine Fast, Charlotte Schröder, Elke Lange, Albrecht Gröner, Wolfram Schäfer, Martin H. Groschup. High sensitivity of domestic pigs to intravenous infection with HEV. BMC Vet Res. 2018; 14: 381. Published online 2018 Dec 4. doi: 10.1186/s12917-018-1713-8

Anne Balkema-Buschmann, Melanie Rissmann, Nils Kley, Reiner Ulrich, Martin Eiden, Martin H. Groschup. Productive Propagation of Rift Valley Fever Phlebovirus Vaccine Strain MP-12 in Rousettus aegyptiacus Fruit Bats. Viruses. 2018 Dec; 10(12): 681. Published online 2018 Nov 30. doi: 10.3390/v10120681

Dorothee E. Scheuch, Mandy Schäfer, Martin Eiden, Eva C. Heym, Ute Ziegler, Doreen Walther, Jonas Schmidt-Chanasit, Markus Keller, Martin H. Groschup, Helge Kampen. Detection of Usutu, Sindbis, and Batai Viruses in Mosquitoes (Diptera: Culicidae) Collected in Germany, 2011–2016. Viruses. 2018 Jul; 10(7): 389. Published online 2018 Jul 23. doi: 10.3390/v10070389

Friederike Michel, Dominik Fischer, Martin Eiden, Christine Fast, Maximilian Reuschel, Kerstin Müller, Monika Rinder, Sylvia Urbaniak, Florian Brandes, Rebekka Schwehn, Renke Lühken, Martin H. Groschup, Ute Ziegler. West Nile Virus and Usutu Virus Monitoring of Wild Birds in Germany. Int J Environ Res Public Health. 2018 Jan; 15(1): 171. Published online 2018 Jan 22. doi: 10.3390/ijerph15010171

 

Bild Caroline Herr

Institut: Bayerischen Landesamt für Gesundheit und Lebensmittelsicherheit

Expertisen: Fachärztin für Hygiene und Umweltmedizin, Stellvertretende Abteilungsleiterin Landesinstitut für Arbeitsschutz und Produktsicherheit; umweltbezogener Gesundheitsschutz (AP); Professorin für Umweltbezogenen Gesundheitsschutz und Prävention am Institut und Poliklinik für Arbeits- Sozial- und Umweltmedizin, Klinikum der Ludwig-Maximilians-Universität München; Präsidentin der Gesellschaft für Hygiene, Umweltmedizin und Präventivmedizin, Vorsitzende der Kommission Umweltmedizin und Environmental Public Health des RKI/UBA; Vorsitzende des Gemeinschaftsausschusses „Bioaerosole und biologische Agenzien“ der VDI/DIN-Kommission Reinhaltung der Luft

Forschungsinteressen: Umweltbezogener Gesundheitsschutz und Klinische Umweltmedizin, Krankenhaushygiene und Infektionskontrolle

Wichtige Publikationen (aus den letzten 5 Jahren):

Zamfir M, Gerstner DG, Walser SM, Bünger J, Eikmann T, Heinze S, Kolk A, Nowak D, Raulf M, Sagunski H, Sedlmaier N, Suchenwirth R, Wiesmüller GA, Wollin KM, Tesseraux I, Herr CEW. A systematic review of experimental animal studies on microbial bioaerosols: Dose-response data for the derivation of exposure limits. Int J Hyg Environ Health. 2019 Mar; 222(2):249-259. doi: 10.1016/j.ijheh.2018.11.004. Epub 2018 Nov 27. PubMed PMID: 30497988.

Kutzora S, Weber A, Heinze S, Hendrowarsito L, Nennstiel-Ratzel U, von Mutius E, Fuchs N, Herr C; GME Study Group. Asthmatic/wheezing phenotypes in preschool children: Influential factors, health care and urban-rural differences. Int J Hyg Environ Health. 2018 Mar; 221(2):293-299. doi: 10.1016/j.ijheh.2017.12.001. Epub 2017 Dec 24. PubMed PMID: 29330038.

Zamfir M, Adler AC, Kolb S, Dammeyer A, Nasri L, Schomacher L, Karlin B, Franitza M, Hörmansdorfer S, Tuschak C, Valenza G, Ochmann U, Herr C. Evaluation of sampling locations in pregnant women and newborns for the detection of colonisation with antibiotic-resistant bacteria. Eur J Clin Microbiol Infect Dis. 2017 Oct; 36(10):1819-1826. doi: 10.1007/s10096-017-2997-5. Epub 2017 May 4. PubMed PMID: 28474179.

Walser SM, Brenner B, Wunderlich A, Tuschak C, Huber S, Kolb S, Niessner R, Seidel M, Höller C, Herr CEW. Detection of Legionella-contaminated aerosols in the vicinity of a bio-trickling filter of a breeding sow facility - A pilot study. Sci Total Environ. 2017 Jan 1;575:1197-1202. doi:10.1016/j.scitotenv.2016.09.191. Epub 2016 Sep 28. PubMed PMID: 27692939.

Walser SM, Gerstner DG, Brenner B, Höller C, Liebl B, Herr CE. Assessing the environmental health relevance of cooling towers--a systematic review of legionellosis outbreaks. Int J Hyg Environ Health. 2014 Mar; 217(2-3):145-54. doi:10.1016/j.ijheh.2013.08.002. Epub 2013 Sep 9. Review. PubMed PMID: 24100053.

Liang LA, Weber A, Herr C, Hendrowarsito L, Meyer N, Bolte G, Nennstiel-Ratzel U, Kolb S; GME Study Group. Children's exposure to second-hand smoke before and after the smoking ban in Bavaria-a multiple cross-sectional study. Eur J Public Health. 2016 Dec;26(6):969-974. doi: 10.1093/eurpub/ckw099. Epub 2016 Jul 14. PubMed PMID: 27418584.

Weber A, Herr C, Hendrowarsito L, Meyer N, Nennstiel-Ratzel U, von Mutius E, Bolte G, Colon D, Kolb S; GME Study Group. No further increase in the parent reported prevalence of allergies in Bavarian preschool children: Results from three cross-sectional studies. Int J Hyg Environ Health. 2016 Jul;219(4-5):343-8. doi: 10.1016/j.ijheh.2016.02.001. Epub 2016 Feb 15. PubMed PMID: 26944211.

Adler AC, Zamfir M, Hendrowarsito L, Dammeyer A, Schomacher L, Karlin B, Franitza M, Nasri L, Hörmansdorfer S, Tuschak C, Valenza G, Ewert T, Hierl W, Ochmann U, Herr C, Heinze S. Hospitalization cost at childbirth: Health parameters and colonization with antimicrobial resistant bacteria and methicillin susceptible Staphylococcus aureus. Eur J Obstet Gynecol Reprod Biol. 2017 Aug;215:20-27. doi: 10.1016/j.ejogrb.2017.05.022. Epub 2017 May 30. PubMed PMID: 28595057.

Bild_Reimar_Johne

Institut: Bundesinstitut für Risikobewertung

Expertisen: Fachtierarzt für Virologie; Diagnostik; Epidemiologie; Public Health

Forschungsinteressen: Nachweis und Charakterisierung Lebensmittel-assoziierter Viren; Untersuchung von Übertragungswegen von Viren in der Lebensmittelkette und Umwelt; Entwicklung von Strategien zum Schutz vor Lebensmittel-bedingten Virusinfektionen; Identifizierung und Charakterisierung neuer Viren und Analyse ihres zoonotischen Potentials

Wichtige Publikationen (aktuelle Auswahl):

Johne, R., Tausch, S.H., Grützke, J., Falkenhagen, A. Patzina-Mehling, C., Beer, M., Höper, D., Ulrich, R.G. (2019): Distantly Related Rotaviruses in Common Shrews, Germany, 2004-2014. Emerging Infectious Diseases, 25, 2310-2314.

Falkenhagen, A., Patzina-Mehling, C., Rückner, A., Vahlenkamp, T.W.,  Johne, R. (2019): Generation of Simian Rotavirus Reassortants with Diverse VP4 Genes Using Reverse Genetics. Journal of General Virology, 100, 1595-1604.

Althof, N., Trojnar, E., Böhm, T., Burkhardt, S., Carl, A., Contzen, M., Kilwinski, J., Mergemeier, S., Moor, D., Mäde, D., Johne, R. (2019): Interlaboratory validation of a method for hepatitis E virus RNA detection in meat and meat products. Food and Environmental Virology, 11:1-8.

Bartsch, C., Plaza-Rodriguez, C., Trojnar, E., Filter, M., Johne, R. (2019):  Predictive models for thermal inactivation of human norovirus and surrogates in strawberry puree. Food Control, 96, 87-97.

Spahr, C., Knauf-Witzens, T., Vahlenkamp, T., Ulrich, R.G.,  Johne, R. (2018): Hepatitis E Virus and Related Viruses in Wild, Domestic and Zoo Animals: a Review. Zoonoses and Public Health, 65, 11–29.

Bild_Sandra_Junglen

Institut: Institut für Virologie, Charité - Universitätsmedizin Berlin

Expertisen: Arbovirologie, Evolution und Ökologie von Arboviren, virale Diversiät, Ökologie von Infektionskrankheiten

Forschungsinteressen: Evolution und Ökologie von arthropodenassoziierten Viren, Mechanismen geographischer Virusausbreitung, Entstehung epidemischer Virusvarianten, genetische Diversität arthropodenassoziierter Viren, Charakterisierung neuartiger Viren

Wichtige Publikationen (aktuelle Auswahl):

Käfer S, Paraskevopoulou S, Zirkel F, Wieseke N, Donath A, Petersen M, Jones TC, Liu S, Zhou X, Middendorf M, Junglen S, Misof B, Drosten C. Re-assessing the diversity of negative strand RNA viruses in insects. PLoS Pathog. 2019 Dec 12;15(12):e1008224. doi: 10.1371/journal.ppat.1008224. eCollection 2019 Dec.

Hermanns K, Marklewitz M, Zirkel F, Overheul GJ, Page RA, Loaiza JR, Drosten C, van Rij RP, Junglen S. Agua Salud alphavirus defines a novel lineage of insect-specific alphaviruses discovered in the New World. J Gen Virol. 2019 Nov 1. doi: 10.1099/jgv.0.001344.

Kopp A, Hübner A, Zirkel F, Hobelsberger D, Estrada A, Jordan I, Gillespie TR, Drosten C, Junglen S. Detection of Two Highly Diverse Peribunyaviruses in Mosquitoes from Palenque, Mexico. Viruses. 2019 Sep 7;11(9). pii: E832. doi: 10.3390/v11090832.

Walker PJ, Siddell SG, Lefkowitz EJ, Mushegian AR, Dempsey DM, Dutilh BE, Harrach B, Harrison RL, Hendrickson RC, Junglen S, Knowles NJ, Kropinski AM, Krupovic M, Kuhn JH, Nibert M, Rubino L, Sabanadzovic S, Simmonds P, Varsani A, Zerbini FM, Davison AJ. Changes to virus taxonomy and the International Code of Virus Classification and Nomenclature ratified by the International Committee on Taxonomy of Viruses (2019). Arch Virol. 2019 Sep;164(9):2417-2429. doi: 10.1007/s00705-019-04306-w.

Marklewitz M, Dutari LC, Paraskevopoulou S, Page RA, Loaiza JR, Junglen S. Diverse novel phleboviruses in sandflies from the Panama Canal area, Central Panama. J Gen Virol. 2019 Jun;100(6):938-949. doi: 10.1099/jgv.0.001260. Epub 2019 May 3.

Tchouassi DP, Marklewitz M, Chepkorir E, Zirkel F, Agha SB, Tigoi CC, Koskei E, Drosten C, Borgemeister C, Torto B, Junglen S, Sang R. Sand Fly-Associated Phlebovirus with Evidence of Neutralizing Antibodies in Humans, Kenya. Emerg Infect Dis. 2019 Apr;25(4):681-690. doi: 10.3201/eid2504.180750.

Hermanns K., Göhner C., Kopp A., Schmidt A., Merz W.M., Markert U.R., Junglen S., Drosten C. (2018). Zika virus infection in human placental tissue explants is enhanced in the presence of dengue virus antibodies in-vitro. Emerging Microbes and Infection 7: 198.

Junglen S., Korries M., Grasse W., Wieseler J., Kopp A., Hermanns K., León-Juárez M., Drosten C., Kümmerer B.M. (2017). Host Range Restriction of Insect-Specific Flaviviruses Occurs at Several Levels of the Viral Life Cycle. mSphere 2 (1). doi: 10.1128/mSphere.00375-16.

PD Dr. Fabian Leendertz

Institut: Robert Koch-Institut, Projektgruppe hochpathogener Erreger http://www.leendertz-lab.org

Expertisen: Fachtierarzt für Mikrobiologie; Zoonotische Infektionen in den Tropen, Epidemiologie, Ökologie, Wildtierkrankheiten, umfassende Surveillance bei Mensch und Tier

Forschungsinteressen: Zoonotische Infektionen bei Mensch und Tier in den Tropen sowie ökologischen und demographischen Faktoren die diese beeinflussen. Wir arbeiten stets im Rahmen des "One Health" Konzeptes und in enger Kooperation mit Partnern aus Afrika

Wichtige Publikationen (Auswahl): 

Gogarten JF, Dux A, Mubemba B, Pleh K, Hoffmann C, Mielke A, Muller-Tiburtius J, Sachse A, Wittig RM, Calvignac-Spencer S, Leendertz FH. 2019. Tropical rainforest flies carrying pathogens form stable associations with social non-human primates. Mol Ecol doi:10.1111/mec.15145.

Gogarten JF, Davies TJ, Benjamino J, Gogarten JP, Graf J, Mielke A, Mundry R, Nelson MC, Wittig RM, Leendertz FH, Calvignac-Spencer S. 2018. Factors influencing bacterial microbiome composition in a wild non-human primate community in Tai National Park, Cote d'Ivoire. ISME J 12:2559-2574.

Hoffmann C, Zimmermann F, Biek R, Kuehl H, Nowak K, Mundry R, Agbor A, Angedakin S, Arandjelovic M, Blankenburg A, Brazolla G, Corogenes K, Couacy-Hymann E, Deschner T, Dieguez P, Dierks K, Dux A, Dupke S, Eshuis H, Formenty P, Yuh YG, Goedmakers A, Gogarten JF, Granjon AC, McGraw S, Grunow R, Hart J, Jones S, Junker J, Kiang J, Langergraber K, Lapuente J, Lee K, Leendertz SA, Leguillon F, Leinert V, Lohrich T, Marrocoli S, Matz-Rensing K, Meier A, Merkel K, Metzger S, Murai M, Niedorf S, De Nys H, Sachse A, van Schijndel J, Thiesen U, Ton E, Wu D, Wieler LH, Boesch C, Klee SR, Wittig RM, Calvignac-Spencer S, Leendertz FH. 2017. Persistent anthrax as a major driver of wildlife mortality in a tropical rainforest. Nature 548:82-86.

Patrono LV, Samuni L, Corman VM, Nourifar L, Rothemeier C, Wittig RM, Drosten C, Calvignac-Spencer S, Leendertz FH. 2018. Human coronavirus OC43 outbreak in wild chimpanzees, Cote d Ivoire, 2016. Emerg Microbes Infect 7:118.

Antonation KS, Grutzmacher K, Dupke S, Mabon P, Zimmermann F, Lankester F, Peller T, Feistner A, Todd A, Herbinger I, de Nys HM, Muyembe-Tamfun JJ, Karhemere S, Wittig RM, Couacy-Hymann E, Grunow R, Calvignac-Spencer S, Corbett CR, Klee SR, Leendertz FH. 2016. Bacillus cereus Biovar Anthracis Causing Anthrax in Sub-Saharan Africa-Chromosomal Monophyly and Broad Geographic Distribution. Plos Neglected Tropical Diseases 10.

Calvignac-Spencer S, Leendertz SAJ, Gillespie TR, Leendertz FH. 2012. Wild great apes as sentinels and sources of infectious disease. Clinical Microbiology and Infection 18:521-527.

Calvignac-Spencer S, Merkel K, Kutzner N, Kuhl H, Boesch C, Kappeler PM, Metzger S, Schubert G, Leendertz FH. 2013. Carrion fly-derived DNA as a tool for comprehensive and cost-effective assessment of mammalian biodiversity. Molecular Ecology 22:915-924.

Coscolla M, Lewin A, Metzger S, Maetz-Rennsing K, Calvignac-Spencer S, Nitsche A, Dabrowski PW, Radonic A, Niemann S, Parkhill J, Couacy-Hymann E, Feldman J, Comas I, Boesch C, Gagneux S, Leendertz FH. 2013. Novel Mycobacterium tuberculosis Complex Isolate from a Wild Chimpanzee. Emerging Infectious Diseases 19:969-976.

Grutzmacher KS, Kondgen S, Keil V, Todd A, Feistner A, Herbinger I, Petrzelkova K, Fuh T, Leendertz SA, Calvignac-Spencer S, Leendertz FH. 2016. Codetection of Respiratory Syncytial Virus in Habituated Wild Western Lowland Gorillas and Humans During a Respiratory Disease Outbreak. Ecohealth 13:499-510.

Kaiser M, Lowa A, Ulrich M, Ellerbrok H, Goffe AS, Blasse A, Zommers Z, CouacyHymann E, Babweteera F, Zuberbuhler K, Metzger S, Geidel S, Boesch C, Gillespie TR, Leendertz FH. 2010. Wild Chimpanzees Infected with 5 Plasmodium Species. Emerging Infectious Diseases 16:1956-1959.

Bild Stephan Ludwig

Institut: Institut für Virologie, Universität Münster

Expertisen: Humanmedizin, Virologie, Zellbiologie

Forschungsinteressen: Zoonotische Influenza Viren, Zellbiologie von respiratorischen Virusinfektionen, neue antivirale Strategien

Wichtige Publikationen (aktuelle Auswahl):

Ludwig S, Hrincius ER, Boergeling Y (2019) The Two Sides of the Same Coin-Influenza Virus and Intracellular Signal Transduction..Cold Spring Harb Perspect Med. 2019 Dec 30. pii: a038513 (Review)

Preugschas HF, Hrincius ER, Mewis C, Tran GVQ, Ludwig S, and Ehrhardt C. (2019) Late activation of the Raf/MEK/ERK pathway is required for translocation of the RSV F protein to the plasma membrane and efficient viral replication. Cellular Microbiology. 17:e12955.

Boergeling Y, Rozhdestvensky TS, Schmolke M, Resa-Infante P, Robeck T, Randau G, Wolff T, Gabriel G, Brosius J, and Ludwig S (2015) Evidence for a Novel Mechanism of Influenza Virus-Induced Type I Interferon Expression by a Defective RNA-Encoded Protein. PLoS Pathogens. 11:e1004924

Liedmann S, Hrincius ER, Guy C, Anhlan D, Dierkes R, Carter R, Wu G, Staeheli P, Green D, Wolff T, McCullers JA, Ludwig S, and Ehrhardt C (2014) Viral suppressors of the RIG-I-mediated interferon response are pre-packaged in influenza virions. Nature Communications 5, 5645

Zell, R., Scholtissek, C., and Ludwig, S. (2013) Genetics, evolution, and the zoonotic capacity of European Swine influenza viruses. Current topics in microbiology and immunology 370, 29-55 (Review)

 

Bild

Institut: Universitätsklinikum Erlangen

Expertisen: Mikrobiologie, Immunologie

Forschungsinteressen: 

Wichtige Publikationen (Auswahl):

Cordsmeier A, Wagner N, Lührmann A, Berens C. Defying Death - How Coxiella burnetii Copes with Intentional Host Cell Suicide. Yale J Biol Med. 2019 Dec 20;92(4):619-628. eCollection 2019 Dec. Review.

Hayek I, Fischer F, Schulze-Luehrmann J, Dettmer K, Sobotta K, Schatz V, Kohl L, Boden K, Lang R, Oefner PJ, Wirtz S, Jantsch J, Lührmann A. Limitation of TCA Cycle Intermediates Represents an Oxygen-Independent Nutritional Antibacterial Effector Mechanism of Macrophages.  Cell Rep. 2019 Mar 26;26(13):3502-3510.e6. doi: 10.1016/j.celrep.2019.02.103.

Kohl L, Hayek I, Daniel C, Schulze-Lührmann J, Bodendorfer B, Lührmann A, Lang R. MyD88 Is Required for Efficient Control of Coxiella burnetii Infection and Dissemination. Front Immunol. 2019 Feb 8;10:165. doi: 10.3389/fimmu.2019.00165. eCollection 2019.

Hayek I, Berens C, Lührmann A. Modulation of host cell metabolism by T4SS-encoding intracellular pathogens. Curr Opin Microbiol. 2019 Feb;47:59-65. doi: 10.1016/j.mib.2018.11.010. Epub 2019 Jan 11. Review.

Krampen L, Malmsheimer S, Grin I, Trunk T, Lührmann A, de Gier JW, Wagner S. Revealing the mechanisms of membrane protein export by virulence-associated bacterial secretion systems. Nat Commun. 2018 Aug 27;9(1):3467. doi: 10.1038/s41467-018-05969-w.

Bild Michael Mühlebach

Expertisen: Veterinärimpfstoffe, Erzeugung (rekombinanter) Masernviren, neu auftretende Erreger, onkolytische Viren, Xenograft Tumormodelle,

Forschungsinteressen: Rekombinante Masernimpfviren als Plattformtechnologie zur Erzeugung bivalenter Impfstoffe; Virus-Wirts-Interaktion von Masern(impf)viren, insbesondere mit dem Immunsystem; Verbesserung der Impfstoffprüfung u.a. unter 3R-Gesichtspunkten; Onkolyse mit zielgerichteten Masernimpfviren

Wichtige Publikationen (Auswahl):

Nürnberger C†, Bodmer BS†, Fiedler AH, Gabriel G, Mühlebach MD: “A measles virus-based vaccine candidate mediates protection against Zika virus in an allogenic mouse pregnancy model” J Virol 93(3): e01485-18 1-15 (2019). †equally contributed

Malczyk AH, Kupke A, Prüfer S, Scheuplein VA, Hutzler S, Kreuz D, Beissert T, Bauer S, Hubich-Rau S, Tondera C, Shams-Eldin H, Schmidt J, Vergara-Alert J, Süzer Y, Seifried J, Hanschmann K-M, Kalinke U, Herold S, Sahin U, Cichutek K, Waibler Z, Eickmann M, Becker S, Mühlebach MD: “A highly immunogenic and protective MERS-Coronavirus vaccine based on recombinant MV vaccine platform” J Virol 89(22): 11654-67 (2015).

Bodmer BS, Fiedler AH, Hanauer JRH, Prüfer S, Mühlebach MD: „Live-attenuated bivalent Measles Virus-derived vaccines targeting Middle East Respiratory Syndrome Coronavirus induce robust and multifunctional T cell responses against both viruses in an appropriate mouse model” Virology 521: 99-107 (2018).

Mühlebach MD, Mateo M, Sinn PL, Prüfer S, Uhlig KM, Leonard VHJ, Navaratnarajah CK, Frenzke M, Wong XX, Sawatsky B, Ramachandran S, McCray, Jr. PB, Cichutek K, von Messling V, Lopez M, Cattaneo R: “Adherens junction protein nectin-4 is the epithelial receptor for measles virus” Nature 480(7378): 530-3 (2011).

Hutzler S, Erbar S, Jabulowsky RA, Hanauer JRH, Schnotz JH, Beissert T, Bodmer BS, Eberle R, Boller K, Klamp T, Sahin U, Mühlebach MD: “Antigen-specific oncolytic MV-based tumor vaccines through presentation of selected tumor-associated antigens on virus-like particles” Sci. Rep. 7: 16892 (2017).

Bild Ruth Müller

Institut: Institut für Tropenmedizin Antwerpen / Goethe Universität Frankfurt am Main

Expertisen: Medizinische Entomologie, Aquatische Ökologie und Ökotoxikologie, EcoHealth

Forschungsinteressen: Vernachlässigte Tropenkrankheiten, Malaria, Vektorbiologie, insbesondere Anpassung von Stechmücken an den Klimawandel; biologische, chemische und genetische Vektorkontrolle; Sozialökologie; Triade Biodiversität, Gesundheit & Klimawandel

Wichtige Publikationen (Auswahl):

Müller, R., Reuss, F., Kendrovski, V., Montag, D. (2019) Vector-borne diseases. In: Marselle MR, Stadler J, Korn H, Irvine KN, Bonn A (Eds) Biodiversity and Health in the Face of Climate Change. Springer, Switzerland.

Hasyim, H., Dhimal, M., Bauer, J., Montag, D., Groneberg, D.A., Kuch, U., Müller, R. (2018) Does livestock protect from malaria or facilitate malaria prevalence? A cross-sectional study in endemic rural areas of Indonesia. Malaria Journal 17(1):302

Müller, R., Knautz, T., Vollroth, S., Berger, R., Kreß, A., Reuss, F., Groneberg, D.A., Kuch, U. (2018) Larval superiority of Culex pipiens to Aedes albopictus in a replacement series experiment: prospects for coexistence in Germany. Parasites & Vectors 11:80

Reuss, F., Wieser, A., Niamir, A., Bálint, M., Kuch, U., Pfenninger, M., Müller, R. (2018) Thermal experiments with the Asian bush mosquito (Aedes japonicus japonicus) (Diptera: Culicidae) and implications for its distribution in Germany. Parasites & Vectors 11:81

Oppold, A., Müller, R. (2017) Epigenetics - A hidden target of insecticides. In: Insect epigenetics. Eds. Russell Jurenka, Heleen Verlinden, Advances in Insect Physiology 53, Academic Press, ISBN 9780128118337

Montag, D., Kuch, U., Rodriguez, L., Müller, R. (2017) Overview of the panel on biodiversity and health under climate change, 91-108, In: Secretariat of the Convention on Biological Diversity. The Lima Declaration on Biodiversity and Climate Change: Contributions from Science to Policy for Sustainable Development. Technical Series No.89. (Eds L. Rodríguez & I. Anderson), Secretariat of the Convention on Biological Diversity, Montreal, 156 pages.

Kabir, M.I., Dhimal, M., Müller, R., Banik, S., Haque, U. (2017) The 2017 Dhaka chikungunya outbreak. The Lancet Infectious Diseases 17, 1118

Kreß, A., Oppold, A.-M., Kuch, U., Oehlmann, J., Müller, R. (2017) Cold tolerance of the Asian tiger mosquito Aedes albopictus and its response to epigenetic alterations. Journal of Insect Physiology 99, 113-121

Kreß, A., Kuch, U., Oehlmann, J., Müller, R. (2016) Effects of diapause and cold acclimation on egg ultrastructure reveal new insights to the cold hardiness mechanisms of the Asian tiger mosquito Aedes (Stegomyia) albopictus. Journal of Vector Ecology 41(1).

Lozán, J.L., Breckle, S.-W., Müller, R., Rachor, E. (2016) Warnsignal Klima: Biodiversität. Unter Berücksichtigung von Habitatveränderungen, Umweltverschmutzung und Globalisierung. 352 pp., Verlag Wissenschaftliche Auswertungen, Hamburg, ISBN 9783980966818. doi:10.2312/warnsignal.klima.die-biodiversitaet.20.

Bild Ard Nijhof

Institut: Institut für Parasitologie und Tropenveterinärmedizin, Freie Universität Berlin

Expertisen: Veterinärmedizin, Parasitologie, Arachno-Entomologie, Tropische Parasitosen

Forschungsinteressen: Erforschung von Wechselwirkungen zwischen Wirt, Zecken und Pathogenen, Entwicklung von Alternativmethoden zum Tierversuch, Molekulardiagnostik

Wichtige Publikationen (Auswahl)

de la Fuente J, Antunes S, Bonnet S, Cabezas-Cruz A, Domingos AG, Estrada-Pena A, Johnson N, Kocan KM, Mansfield KL, Nijhof AM et al: Tick-Pathogen Interactions and Vector Competence: Identification of Molecular Drivers for Tick-Borne Diseases. Front Cell Infect Microbiol 2017, 7:114.

Hailemariam Z, Ahmed JS, Clausen PH, Nijhof AM: A comparison of DNA extraction protocols from blood spotted on FTA cards for the detection of tick-borne pathogens by Reverse Line Blot hybridization. Ticks Tick Borne Dis 2017, 8(1):185-189.

Krull C, Bohme B, Clausen PH, Nijhof AM: Optimization of an artificial tick feeding assay for Dermacentor reticulatus. Parasit Vectors 2017, 10(1):60.

Knorr S, Anguita J, Cortazar JT, Hajdusek O, Kopacek P, Trentelman JJ, Kershaw O, Hovius JW, Nijhof AM: Preliminary Evaluation of Tick Protein Extracts and Recombinant Ferritin 2 as Anti-tick Vaccines Targeting Ixodes ricinus in Cattle. Front Physiol 2018, 9:1696.

Roy BC, Estrada-Pena A, Krucken J, Rehman A, Nijhof AM: Morphological and phylogenetic analyses of Rhipicephalus microplus ticks from Bangladesh, Pakistan and Myanmar. Ticks Tick Borne Dis 2018, 9(5):1069-1079.

Roy BC, Krucken J, Ahmed JS, Majumder S, Baumann MP, Clausen PH, Nijhof AM: Molecular identification of tick-borne pathogens infecting cattle in Mymensingh district of Bangladesh reveals emerging species of Anaplasma and Babesia. Transbound Emerg Dis 2018, 65(2):e231-e242.

Sprong H, Azagi T, Hoornstra D, Nijhof AM, Knorr S, Baarsma ME, Hovius JW: Control of Lyme borreliosis and other Ixodes ricinus-borne diseases. Parasit Vectors 2018, 11(1):145.

Bild Martin Pfeffer

Institut: Institut für Tierhygiene und Öffentliches Veterinärwesen, Universität Leipzig

Expertisen: Tiermedizin, Epidemiologie, Public Health

Forschungsinteressen: Epidemiologie von Vektor-übertragenen Zoonosen (viral, bakteriell, Einzeller) mit Schwerpunkt auf Arboviren und Stechmücken, Zecken und Zecken-übertragenen Pathogenen, sowie die Ökologie der Zecken und ihrer Wirte

Aktuelle Publikationen (Auswahl):

Chitimia-Dobler L, Lemhöfer G, Król N, Bestehorn M, Dobler G, Pfeffer M (2019) Continuous isolation of Tick-borne encephalitis virus from adult Dermacentor reticulatus ticks in an endemic area in Germany. Parasites & Vectors 12:90 doi: 10.1186/s13071-019-3346-6

Król N, Obiegala A, Kretschmar FM, Hamel D, Pfeffer M (2019) The European polecat, Mustela putorius – a host for ticks but not for tick-borne pathogens? Ticks Tick-Borne Diseases 10, 594-597 doi: 10.1016/j.ttbdis.2019.02.004

Obiegala A, Heuser E, Ryll, R, Imholt C, Fürst J, Prautsch LM, Plenge-Bönig A, Ulrich RG, Pfeffer M (2019) Norway rats in Europe: Potential reservoirs for zoonotic arthropod-borne pathogens? Pest Management Science 75, 1556-1563 doi: 10.1002/ps.5223

Obiegala A, Jeske K, Augustin M, Król N, Fischer S, Mertens-Scholz K, Imholt C, Suchomel J, Heroldova M, Tomaso H, Ulrich RG, Pfeffer M (2019) Highly prevalent bartonellae and other vector-borne pathogens in small mammal species from the Czech Republic and Germany. Parasites & Vectors 12:332 doi: 10.1186/s13071-019-3576-7

Lundström JO, Hesson JC, Schäfer M, Östman Ö, Semmler T, Weidmann M, Lundkvist A, Pfeffer M (2019) Sindbis virus polyarthritis outbreak signaled by virus prevalence in the mosquito vectors. PLoS Neglected and Tropical Diseases 13(8):e0007702 doi: 10.1371/journal.pntd.0007702.

Schmidt-Chanasit (BNITM)

Institut: Bernhard-Nocht-Institut für Tropenmedizin, WHO Collaborating Centre for Arbovirus and Haemorrhagic Fever Reference and Research; Universität Hamburg

Expertisen: Arboviren

Forschungsinteressen: 

Wichtige Publikationen (Auswahl):

Schlottau K, Forth L, Angstwurm K, Höper D, Zecher D, Liesche F, Hoffmann B, Kegel V, Seehofer D, Platen S, Salzberger B, Liebert UG, Niller HH, Schmidt B, Matiasek K, Riemenschneider MJ, Brochhausen C, Banas B, Renders L, Moog P, Wunderlich S, Seifert CL, Barreiros A, Rahmel A, Weiss J, Tappe D, Herden C, Schmidt-Chanasit J, Schwemmle M, Rubbenstroth D, Schlegel J, Pietsch C, Hoffmann D, Jantsch J, Beer M. Fatal Encephalitic Borna Disease Virus 1 in Solid-Organ Transplant Recipients. N Engl J Med. 2018 Oct 4;379(14):1377-1379. doi: 10.1056/NEJMc1803115.

Negredo A, de la Calle-Prieto F, Palencia-Herrejón E, Mora-Rillo M, Astray-Mochales J, Sánchez-Seco MP, Bermejo Lopez E, Menárguez J, Fernández-Cruz A, Sánchez-Artola B, Keough-Delgado E, Ramírez de Arellano E, Lasala F, Milla J, Fraile JL, Ordobás Gavín M, Martinez de la Gándara A, López Perez L, Diaz-Diaz D, López-García MA, Delgado-Jimenez P, Martín-Quirós A, Trigo E, Figueira JC, Manzanares J, Rodriguez-Baena E, Garcia-Comas L, Rodríguez-Fraga O, García-Arenzana N, Fernández-Díaz MV, Cornejo VM, Emmerich P, Schmidt-Chanasit J, Arribas JR. Autochthonous Crimean–Congo Hemorrhagic Fever in Spain. N Engl J Med. 2017 Jul 13;377(2):154-161. doi: 10.1056/NEJMoa1615162.

Agnandji ST, Huttner A, Zinser ME, Njuguna P, Dahlke C, Fernandes JF, Yerly S, Dayer JA, Kraehling V, Kasonta R, Adegnika AA, Altfeld M, Auderset F, Bache EB, Biedenkopf N, Borregaard S, Brosnahan JS, Burrow R, Combescure C, Desmeules J, Eickmann M, Fehling SK, Finckh A, Goncalves AR, Grobusch MP, Hooper J, Jambrecina A, Kabwende AL, Kaya G, Kimani D, Lell B, Lemaître B, Lohse AW, Massinga-Loembe M, Matthey A, Mordmüller B, Nolting A, Ogwang C, Ramharter M, Schmidt-Chanasit J, Schmiedel S, Silvera P, Stahl FR, Staines HM, Strecker T, Stubbe HC, Tsofa B, Zaki S, Fast P, Moorthy V, Kaiser L, Krishna S, Becker S, Kieny MP, Bejon P, Kremsner PG, Addo MM, Siegrist CA. Phase 1 Trials of rVSV Ebola Vaccine in Africa and Europe. N Engl J Med. 2016 Apr 28;374(17):1647-60. doi: 10.1056/NEJMoa1502924.

Tappe D, Schmidt-Chanasit J, Beer M. Bornavirus Associated with Fatal Human Encephalitis. N Engl J Med. 2015 Nov 5;373(19):1880-1. doi: 10.1056/NEJMc1510342.

Hoffmann B, Tappe D, Höper D, Herden C, Boldt A, Mawrin C, Niederstraßer O, Müller T, Jenckel M, van der Grinten E, Lutter C, Abendroth B, Teifke JP, Cadar D, Schmidt-Chanasit J, Ulrich RG, Beer M. A Variegated Squirrel Bornavirus Associated with Fatal Human Encephalitis. N Engl J Med. 2015 Jul 9;373(2):154-62. doi: 10.1056/NEJMoa1415627.

Kreuels B, Wichmann D, Emmerich P, Schmidt-Chanasit J, de Heer G, Kluge S, Sow A, Renné T, Günther S, Lohse AW, Addo MM, Schmiedel S.A case of severe Ebola virus infection complicated by gram-negative septicemia. N Engl J Med. 2014 Dec 18;371(25):2394-401. doi: 10.1056/NEJMoa1411677.

 

M_Schweizer_IB

Institut: Zweckverband Veterinäramt JadeWeser

Expertisen: Fachtierärztin für Öffentliches Veterinärwesen, gesundheitlicher Verbraucherschutz, operatives Krisenmanagement

 

 

Bild Torsten Semmler

Institut: Leiter der Arbeitsgruppe NG1 – Mikrobielle Genomik, Robert Koch-Institut

Expertisen: Bioinformatik, Mikrobielle Genomik, Populationsgenetik, Molekulare Evolution, antimikrobielle Resistenzen, Metagenomik

Forschungsinteressen: Mechanismen der Evolution und der Verbreitung von pathogenen Mikroorganismen (in Mensch, Tier und Umwelt), untersucht durch bioinformatisch Methoden, basierend auf den Genomdaten in Kombination mit phänotypischen Analysen, um die Virulenz, Transmission und Wirts-Interaktion der Mikroorganismen zu verstehen; Mechanismen der Antimikrobiellen Resistenz (AMR) als eine der wichtigsten evolutionären Kräfte in der Weiterentwicklung von Bakterien

Wichtige Publikationen (Auswahl):

Astrid von Mentzer, Thomas R Connor, Lothar H Wieler, Torsten Semmler, Atsushi Iguchi, Nicholas R Thomson, David A Rasko, Enrique Joffre, Jukka Corander, Derek Pickard, Gudrun Wiklund, Ann-Mari Svennerholm, Asa Sjöling, Gordon Dougan: Identification of enterotoxigenic Escherichia coli (ETEC) clades with long-term global distribution. Nature Genetics 11/2014;, DOI:10.1038/ng.3145

Ramani Baddam, Narender Kumar, Lothar H. Wieler, Aditya Kumar Lankapalli, Niyaz Ahmed, Sharon J. Peacock, Torsten Semmler: Analysis of mutations in pncA reveals non-overlapping patterns among various lineages of Mycobacterium tuberculosis. Scientific Reports 03/2018; 8(1)., DOI:10.1038/s41598-018-22883-9

Katharina Schaufler, Torsten Semmler, Lothar H. Wieler, Darren J. Trott, Johann Pitout, Gisele Peirano, Jonas Bonnedahl, Monika Dolejska, Ivan Literak, Stephan Fuchs, Niyaz Ahmed, Mirjam Grobbel, Carmen Torres, Alan McNally, Derek Pickard, Christa Ewers, Nicholas J. Croucher, Jukka Corander, Sebastian Guenther: Genomic and functional analysis of emerging virulent and multi-drug resistant E. coli lineage ST648. Antimicrobial Agents and Chemotherapy 03/2019; 63(6); DOI:10.1128/AAC.00243-19

Torsten Semmler, Ewan M Harrison, Antina Lübke-Becker, Rainer G Ulrich, Lothar H Wieler, Sebastian Guenther, Ivonne Stamm, Anne-Merethe Hanssen, Mark A Holmes, Szilvia Vincze, Birgit Walther: A Look into the Melting Pot: The mecC-Harboring Region Is a Recombination Hot Spot in Staphylococcus stepanovicii. PLoS ONE 01/2016; 11(1):e0147150., DOI:10.1371/journal.pone.0147150

Connor, T. R., Barker, C. R., Baker, K. S., Weill, F.-X., Talukder, K. A., Smith, A. M., Baker, S., Gouali, M., Thanh, D.P., Azmi, I.J., Dias da Silveira, W., Semmler, T., Wieler, L.H., Jenkins, C., Cravioto, A., Faruque, S.M., Parkhill, J., Kim, D.W., Keddy, K.H., Thomson, N. R. (2015). Species-wide whole genome sequencing reveals historical global spread and recent local persistence in Shigella flexneri. eLife, 4, e07335. http://doi.org/10.7554/eLife.07335

Bild Cornelia Silaghi

Institut: Institut für Infektionsmedizin, Friedrich-Loeffler-Institut; Mathematisch-Naturwissenschaftliche Fakultät, Fachrichtung Biologie, Universität Greifswald

Expertisen: Tiermedizin, Parasitologie, Infektionsbiologie, Vektoren und vektor-übertragene Pathogene

Forschungsinteressen: Vektoren- und durch sie übertragene Pathogene, Vektorkapazität und Vektorkompetenz, Zecken, Stechmücken, Gnitzen, West-Nil-Virus, Dirofilaria spp., Anaplasma phagocytophilum, Koinfektionen, Transkriptom, Vektor-Pathogen-Interaktionen

Wichtige Publikationen (Auswahl letzte 5 Jahre):

Cafarelli C, Russo G, Mathis A, Silaghi C. De novo genome sequencing and comparative stage-specific transcriptomic analysis of Dirofilaria repens. Int J Parasitol. 2019 Nov;49(12):911-919. doi: 10.1016/j.ijpara.2019.04.008. Epub 2019  Sep 23. PubMed PMID: 31557466.

Schenkel CD, Kamber T, Schaffner F, Mathis A, Silaghi C. Loop-mediated isothermal amplification (LAMP) for the identification of invasive Aedes mosquito species. Med Vet Entomol. 2019 Sep;33(3):345-351. doi: 10.1111/mve.12366. Epub 2019 Feb 8. PubMed PMID: 30734975.

Vasić A, Zdravković N, Aniță D, Bojkovski J, Marinov M, Mathis A, Niculaua M, Oșlobanu EL, Pavlović I, Petrić D, Pflüger V, Pudar D, Savuţa G, Simeunović P, Veronesi E, Silaghi C; SCOPES AMSAR training group. Species diversity, host preference and arbovirus detection of Culicoides (Diptera: Ceratopogonidae) in south-eastern Serbia. Parasit Vectors. 2019 Jan 25;12(1):61. doi: 10.1186/s13071-019-3292-3. PubMed PMID: 30683145; PubMed Central PMCID: PMC6347842.

Capelli G, Genchi C, Baneth G, Bourdeau P, Brianti E, Cardoso L, Danesi P, Fuehrer HP, Giannelli A, Ionică AM, Maia C, Modrý D, Montarsi F, Krücken J, Papadopoulos E, Petrić D, Pfeffer M, Savić S, Otranto D, Poppert S, Silaghi C. Recent advances on Dirofilaria repens in dogs and humans in Europe. Parasit Vectors. 2018 Dec 19;11(1):663. doi: 10.1186/s13071-018-3205-x. Review. PubMed PMID: 30567586; PubMed Central PMCID: PMC6299983.

Veronesi E, Paslaru A, Silaghi C, Tobler K, Glavinic U, Torgerson P, Mathis A. Experimental evaluation of infection, dissemination, and transmission rates for two West Nile virus strains in European Aedes japonicus under a fluctuating temperature regime. Parasitol Res. 2018 Jun;117(6):1925-1932. doi:10.1007/s00436-018-5886-7. Epub 2018 Apr 28. PubMed PMID: 29705877; PubMed Central PMCID: PMC5949136.

Wagner S, Mathis A, Schönenberger AC, Becker S, Schmidt-Chanasit J, Silaghi C, Veronesi E. Vector competence of field populations of the mosquito species Aedes japonicus japonicus and Culex pipiens from Switzerland for two West Nile virus strains. Med Vet Entomol. 2018 Mar;32(1):121-124. doi: 10.1111/mve.12273. Epub 2017 Oct 30. PubMed PMID: 29082585.

Silaghi C, Beck R, Capelli G, Montarsi F, Mathis A. Development of Dirofilaria immitis and Dirofilaria repens in Aedes japonicus and Aedes geniculatus. Parasit Vectors. 2017 Feb 20;10(1):94. doi: 10.1186/s13071-017-2015-x. PubMed PMID: 28219407; PubMed Central PMCID: PMC5319011.

Schönenberger AC, Wagner S, Tuten HC, Schaffner F, Torgerson P, Furrer S, Mathis A, Silaghi C. Host preferences in host-seeking and blood-fed mosquitoes in Switzerland. Med Vet Entomol. 2016 Mar;30(1):39-52. doi: 10.1111/mve.12155. Epub 2015 Dec 21. PubMed PMID: 26685926.

Vayssier-Taussat M, Kazimirova M, Hubalek Z, Hornok S, Farkas R, Cosson JF, Bonnet S, Vourch G, Gasqui P, Mihalca AD, Plantard O, Silaghi C, Cutler S, Rizzoli A. Emerging horizons for tick-borne pathogens: from the 'one pathogen-one disease' vision to the pathobiome paradigm. Future Microbiol. 2015;10(12):2033-43. doi: 10.2217/fmb.15.114. Epub 2015 Nov 19. Review. PubMed PMID: 26610021; PubMed Central PMCID: PMC4944395.

Wächter M, Wölfel S, Pfeffer M, Dobler G, Kohn B, Moritz A, Pachnicke S, Silaghi C. Serological differentiation of antibodies against Rickettsia helvetica, R. raoultii, R. slovaca, R. monacensis and R. felis in dogs from Germany by a micro-immunofluorescent antibody test. Parasit Vectors. 2015 Mar 23;8:126. doi: 10.1186/s13071-015-0745-1. PubMed PMID: 25889200; PubMed Central PMCID: PMC4369902.

Bild Imke Steffen

Institut: Institut für Physiologische Chemie und Research Center for Emerging Infections and Zoonoses, Stiftung Tierärztliche Hochschule Hannover

 Expertisen: Virologie, zoonotische RNA-Viren, Rhabdoviren, Flaviviren, Filoviren, Serologie, Proteinbiochemie, Interaktion und Funktion viraler Proteine

Forschungsinteressen: Etablierung von Reverse-Genetik- und Replikon-Systemen für Flaviviren, Entdeckung und Analyse differenziell induzierter Wirtsfaktoren in RNA-Virus-infizierten Zellen, Untersuchung der Rolle einzelner viraler Proteine in der wirtsabhängigen Pathogenese, Seroprävalenzstudien für neue und sich verbreitende RNA-Viren, Analyse der humoralen Immunantwort gegen RNA-Viren, Vergleichende Analyse polyklonaler Antikörper-Effektorfunktionen

Wichtige Publikationen (Auswahl):

Steffen I, Lu K, Hoff NA, Mulembakani P, Wemakoy EO, Muyembe-Tamfum J-J, Ndembi N, Brennan CA, Hackett J Jr., Switzer WM, Saragosti S, Mbensa GO, Laperche S, Rimoin AW, Simmons G. (2020) Seroreactivity against Marburg or related filoviruses in West and Central Africa. Emerg Microbes Infect [accepted]

Steffen I, Lu K, Yamamoto LK, Hoff NA, Mulembakani P, Wemakoy EO, Muyembe-Tamfum J-J, Ndembi N, Brennan CA, Hackett J Jr., Stramer SL, Switzer WM, Saragosti S, Mbensa GO, Laperche S, Rimoin AW, Simmons G. (2019) Serologic prevalence of Ebola virus in equatorial Africa. Emerg Infect Dis. 25(5).

Rimoin AW, Lu K, Bramble MS, Steffen I, Doshi RH, Hoff NA, Mukadi P, Nicholson BP, Alfonso VH, Olinger G, Sinai C, Yamamoto LK, Ramirez CM, Okitolonda Wemakoy E, Kebela Illunga B, Pettitt J, Logue J, Bennett RS, Jahrling P, Heymann DL, Piot P, Muyembe-Tamfum JJ, Hensley LE, Simmons G. (2018) Ebola Virus Neutralizing Antibodies Detectable in Survivors of theYambuku, Zaire Outbreak 40 Years after Infection. J Infect Dis. Jan 4;217(2):223-231.

Steffen I and Simmons G. (2015) Emerging Rhabdoviruses. In Biology and Pathogenesis of Rhabdo- and Filoviruses, Editors: A. K. Pattnaik and M. A. Whitt, World Scientific, p. 311-334.

Steffen I, Liss NM, Schneider BS, Fair JN, Chiu CY, Simmons G. (2013) Characterization of the Bas-Congo virus glycoprotein and its function in pseudotyped viruses. J Virol. Sep;87(17):9558-68.

Kiene M, Marzi A, Urbanczyk A, Bertram S, Fisch T, Nehlmeier I, Gnirß K, Karsten CB, Palesch D, Münch J, Chiodi F, Pöhlmann S, Steffen I. (2012) The role of the alternative coreceptor GPR15 in SIV tropism for human cells. Virology. Nov 10;433(1):73-84.

Grard G, Fair JN, Lee D, Slikas E, Steffen I, Muyembe J-J, Sittler T, Veeraraghavan N, Ruby JG, Wang C, Makuwa M, Mulembakani P, Tesh RB, Mazet J, Rimoin AW, Taylor T, Schneider BS, Simmons G, Delwart E, Wolfe ND, Chiu CY, Leroy EM. (2012) A Novel Rhabdovirus Associated with Acute Hemorrhagic Fever in Central Africa. PLoS Pathog. Sep;8(9):e1002924.

Steffen I, Pöhlmann S. (2010) Peptide-based inhibitors of the HIV envelope protein and other class I viral fusion proteins. Curr Pharm Des. 16(9):1143-58.

Steffen I, Tsegaye TS, Pöhlmann S. (2010) Lectin-like interactions in virus-cell recognition: human immunodeficiency virus and C-type lectin interactions. In Microbial Glycobiology: Structures, Relevance and Applications, Elsevier Science, p. 567-584.

Chaipan C*, Steffen I*, Tsegaye TS*, Bertram S, Glowacka I, Kato Y, Schmökel J, Münch J, Simmons G, Gerardy-Schahn R, Pöhlmann S. (2010) Incorporation of podoplanin into HIV released from HEK-293T cells, but not PBMC, is required for efficient binding to the attachment factor CLEC-2. Retrovirology. May 19;7:47.

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Institut: Institut für Virologie, Zentrum für Infektionsmedizin, Stiftung Tierärztliche Hochschule Hannover

Expertisen: 

Forschungsinteressen: Entwicklung neuer Impfstoffe für zoonotische Erreger

Wichtige Publikationen (Auswahl):

Forster D, Schwarz JH, Brosinski K, Kalinke U, Sutter G, Volz A. Obstetric Ultrasonography to Detect Fetal Abnormalities in a Mouse Model for Zika Virus Infection. Viruses. 2020 Jan 7;12(1). pii: E72. doi: 10.3390/v12010072.

Kalodimou G, Veit S, Jany S, Kalinke U, Broder CC, Sutter G, Volz A. A Soluble Version of Nipah Virus Glycoprotein G Delivered by Vaccinia Virus MVA Activates Specific CD8 and CD4 T Cells in Mice. Viruses. 2019 Dec 24;12(1). pii: E26. doi: 10.3390/v12010026.

CD8+ T Cells Responding to the Middle East Respiratory Syndrome Coronavirus Nucleocapsid Protein Delivered by Vaccinia Virus MVA in Mice. Veit S, Jany S, Fux R, Sutter G, Volz A. Viruses. 2018 Dec 16;10(12). pii: E718. doi: 10.3390/v10120718.

Schmidt R., Beltzig L.C., Sawatsky B., Dolnik O., Dietzel E., Krähling V., Volz A., Suter G., Becker S, von Messling V. Generation of therapeutic antisera for emerging viral infections. NPJ Vaccines, 2018 Oct 5, 3:42, doi:10.1038/s41541-0018-0082-4, eCollection

Tappe K.A., Budida R., Stankov M.V., Frenz T., Shah H., Volz A., Sutter G., Kalinke U., Behrens G.M.N. Immunogenic cell death of dendritic cells following modified vaccinia virus Ankara infection enhances CD8+ T cell proliferation. Eur. J. Immunol., 48(12), 2042-2054 (2018)

Langenmayer M., Lülf-Averhoff A-T, Adam-Neumair S., Sutter G., Volz A. Tracking Modified Vaccinia Virus Ankara in the Chicken Embryo: In Vivo Tropism and Pathogenesis of Egg Infections. (pdf, 1,755 KB) Viruses, 10(9), pii: E452 (2018), doi:10.3390/ v10090452.

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Institut: Robert Koch-Institut, Spezielle Licht- und Elektronenmikroskopie (ZBS-4)

Expertisen: 

Forschungsinteressen: antimicrobials, multidrug-resistant microorganisms (MDRO)

Wichtige Publikationen (Auswahl):

Johanns VC, Ghazisaeedi F, Epping L, Semmler T, Lübke-Becker A, Pfeifer Y, Bethe A, Eichhorn I, Merle R, Walther B, Wieler LH. Effects of a Four-Week High-Dosage Zinc Oxide Supplemented Diet on Commensal Escherichia coli of Weaned Pigs. Front Microbiol. 2019 Nov 28;10:2734. doi: 10.3389/fmicb.2019.02734. eCollection 2019.

Scholtzek AD, Hanke D, Walther B, Eichhorn I, Stöckle SD, Klein KS, Gehlen H, Lübke-Becker A, Schwarz S, Feßler AT. Molecular Characterization of Equine Staphylococcus aureus Isolates Exhibiting Reduced Oxacillin Susceptibility. Toxins (Basel). 2019 Sep 13;11(9). pii: E535. doi: 10.3390/toxins11090535.

Walther B, Klein KS, Barton AK, Semmler T, Huber C, Merle R, Tedin K, Mitrach F, Lübke-Becker A, Gehlen H. Equine Methicillin-Resistant Sequence Type 398 Staphylococcus aureus (MRSA) Harbor Mobile Genetic Elements Promoting Host Adaptation. Front Microbiol. 2018 Oct 24;9:2516. doi: 10.3389/fmicb.2018.02516. eCollection 2018.

Trübe P, Hertlein T, Mrochen DM, Schulz D, Jorde I, Krause B, Zeun J, Fischer S, Wolf SA, Walther B, Semmler T, Bröker BM, Ulrich RG, Ohlsen K, Holtfreter S. Bringing together what belongs together: Optimizing murine infection models by using mouse-adapted Staphylococcus aureus strains. Int J Med Microbiol. 2019 Jan;309(1):26-38. doi: 10.1016/j.ijmm.2018.10.007. Epub 2018 Oct 22.

Busche T, Hillion M, Van Loi V, Berg D, Walther B, Semmler T, Strommenger B, Witte W, Cuny C, Mellmann A, Holmes MA, Kalinowski J, Adrian L, Bernhardt J, Antelmann H. Comparative Secretome Analyses of Human and Zoonotic Staphylococcus aureus Isolates CC8, CC22, and CC398. Mol Cell Proteomics. 2018 Dec;17(12):2412-2433. doi: 10.1074/mcp.RA118.001036. Epub 2018 Sep 10.