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ZooBoCo

ZooBoCo

The Zoonotic Bornavirus Consortium (ZooBoCo) is working on the characterisation of the newly discovered variegated squirrel bornavirus 1 (VSBV-1).

Background

Since its initial description in 2015, four deaths have been recorded in Germany due to infections with the new variegated squirrel borna virus (VSBV-1). This unexpected accumulation raises serious concerns about the transmissibility of CSBV-1 and related borna viruses to humans and the pathogenic potential of these viruses. The exact number of horns or humans currently infected with or exposed to potentially dangerous Borna viruses is unknown. It is therefore unclear whether the horns can transmit these viruses or whether there is a reservoir of other hosts that still needs to be identified.

Mission

The research network will generate urgently needed data to better understand the zoonotic potential of these viruses, their characteristic properties and their putative reservoir host species and transmission routes. Furthermore, suitable intervention strategies will be investigated.

Aims

Aim 1: Knowledge of reservoirs, epidemiology and (molecular) biology of CSBV-1 to design a model for novel zoonotic infections

Aim 2: Concepts for the use of next-generation sequencing for metagenome diagnostics of zoonotic infections of the central nervous system (CNS): VSBV-1 as a model for unexplained encephalitis cases

Aim 3: First evaluation of antiviral substances with regard to their effect against CDBV-1 and other Borna viruses

Aim 4: Risk assessment: models for public health services, including the development of new intervention approaches and adaptation of legislation

Coordination

Prof. Dr. Martin Beer
Friedrich-Loeffler-Institut
Institute for Virus Diagnostics
E-Mail: martin.beer(at)fli.de
Tel.: +49 (0)38351 7 1200

List of subproject leaders

TP0:

Prof. Dr. Martin Beer, Friedrich-Loeffler-Institut
Dr. Jürgen Rissland, Universität Saarland, Institut für Virologie

TP1:

PD Dr. Rainer G. Ulrich, Friedrich-Loeffler-Institut
Dr. Bernd Hoffmann, Friedrich-Loeffler-Institut

TP2:

Dr. Dirk Höper, Friedrich-Loeffler-Institut
Prof. Dr. Martin Beer, Friedrich-Loeffler-Institut

TP3:

Dr. Donata Hoffmann, Friedrich-Loeffler-Institut
Prof. Dr. Christiane Herden, Justus-Liebig-Universität
Dr. Heinz Feldmann, National Institute of Allergy and Infection

TP4:

Prof. Dr. Martin Schwemmle, Universitätsklinikum Freiburg
Dr. Dennis Rubbenstroth, Universitätsklinikum Freiburg

TP5+6:

Prof. Dr. Jonas Schmidt-Chanasit, Bernhard-Nocht-Institut für Tropenmedizin
Prof. Dr. Dennis Tappe, Bernhard-Nocht-Institut für Tropenmedizin
Dr. Timo Hohmeier-Bachmann, Friedrich-Loeffler-Institut
Dr. Hendrik Wilking, Robert-Koch-Institut
Prof. Dr. Klaus Stark, Robert-Koch-Institut

TP7:

Dr. Jürgen Rissland, Universität Saarland, Institut für Virologie

Nationale Forschungsplattform für Zoonosen

Koordinationsbüro

c/o Institut für Virologie Charité - Universitätsmedizin Berlin
Campus Charité Mitte
Charitéplatz 1, 10117 Berlin
forschungsnetz@zoonosen.net

Ilia Semmler
Tel.: 030 - 450 525 094
Fax: 030 - 450 75 25 907

Andrea Sieberg
Tel.: 030 - 450 625 484
Fax: 030 - 450 75 25 907