Pilot project: "Establishment of the siRNA-mediated knock down in primary macrophages of different animal species"
Within the pilot project, a small interfering (si)RNA-mediated knock down (RNA interference/silencing) was established in primary avian and bovine macrophages to provide a suitable model for the molecular investigation of host-pathogen interactions in these animal species. Since the inducible nitric oxide synthase (iNOS) is an important factor in host defence against intracellular pathogens such...